Phenotypic Expressions of the Major Histocompatibility Locus in Man (hl-a): Leukocyte Antigens and Mixed Leukocyte Culture Reactivity
نویسندگان
چکیده
The evidence is reviewed that a single genetic system, the major histocompatibility locus in man, HL-A, determines most of the antigens measured by presently available leukocyte isoantisera, and also controls reactivity in one-way mixed leucocyte culture tests. Studies in 12 families are presented to support this conclusion. Some interesting exceptions to the general typing-MLC tests correlation are presented and discussed.
منابع مشابه
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The relationship between the major histocompatibility systems as defined serologically and by the mixed leukocyte culture (MLC) test is one which has received attention in both man (1) and mouse (2). In man, studies within families suggest that cells of siblings who inherit the same HL-A chromosomes from their parents and thus are serologically identical at HL-A do not stimulate in the MLC test...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 128 شماره
صفحات -
تاریخ انتشار 1968